Bioengineering 3D Neural Networks Using Magnetic Manipulations
نویسندگان
چکیده
Controlling nerve cells to form pre-designed 3D neural networks that recapitulate the intricate interconnectivity in brain is essential for developing neuronal interfaces and new regeneration approaches. Here, within biomaterials are dynamically localized using nano-based magnetic manipulations. Nerve transformed into units their organizational layout manipulated external field gradients. Iron oxide nanoparticles incorporated both Pheochromocytoma cell-line 12 (PC12) primary mice cortical neurons magnetized subjected multiple fields arrays. Their movement controlled inside multi-layered collagen scaffolds, which simulate innate properties of in-vivo tissue structures. Via these manipulations, functional microarchitectures created. In light clustered layered structure mammalian central nervous system, this strategy paves way creating customized architectures bioengineering applications, enabling a broad range advanced implementations providing efficient models investigating cellular behavior.
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ژورنال
عنوان ژورنال: Advanced Functional Materials
سال: 2022
ISSN: ['1616-301X', '1616-3028']
DOI: https://doi.org/10.1002/adfm.202204925